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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight-loss in addition to a reduced-calorie diet and exercising. Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people that go through it you should err assisting caution and allow FDA do its job and demand some research be done so that the public understands the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies come in business to generate income and that they would say everything to keep people on the medications. Researchers found that participants investing in this drug to get a year, dropped excess weight within a month and have kept the weight off through the 56 weeks from the study. Contrave can be a combination with the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which might be made up of more than one active ingredient, that might make them more efficient and safer. Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that at the time of right now there aren't any long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and must not be taken in individuals with seizure disorders. The drug also can raise hypertension and heart rate, and mustn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure level and heart rate and must 't be used in patients with uncontrolled high blood pressure, in addition to by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients which has a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stopping smoking. Approving a drug with this many potentially lethal unwanted side effects is inconsistent while using mission statement in the FDA. The power from the drug manufacturing lobby is blatantly evident in the approval of numerous drugs requiring 'post-marketing' studies which are clearly significant to overall drug safety inside the US.